ROME—The leaders went six points clear at the top of the table whilst Marco Parolo scoring four for Lazio against Pescara was the other highlight of the latest Serie A round in which Juventus continued to assert their dominance against other title challengers.

 A spectacular strike from the Colombian Juan Cuadrado gave Juventus, the Serie A leaders, a 1-0 win over Internazionale to end a run of seven successive league wins for their opponents in a frenetic encounter.

 Marco Parolo scored four goals in Lazio’s 6-2 win away at the home of the leagues bottom team, Pescara, whileMilan’s season continued to nosedive as they were booed off the San Siro pitch following a 1-0 home defeat against Sampdoria.

 Juve’s 28th successive home league win left them on 54 points, six clear of Napoli who thumped Bologna 7-1 away in the weekend’s opening game on Saturday. Chasing a sixth successive title Juve also have a game in hand on their pursuers.

 Lazio’s win took them into fourth place with 43 points, four behind Roma who host Fiorentina on Tuesday, and one ahead of Inter and Atalanta.

 Juventus and Inter served up an absorbing first half in Turin with Paulo Dybala and Miralem Pjanic hitting the crossbar for the hosts, who also found Inter’s goalkeeper, Samir Handanovic, in great form as he pulled off save after save.

 Inter had their chances but Juve went ahead in the 43^rd minute when a corner was cleared to the edge of the area. Cuadrado met the loose ball in his stride and fired a magnificent rising shot into the net.

 Handanovic continued to deny Inter in the second half with saves from Pjanic and Mario Mandzukic while the substitute Eder wasted Inter’s best hope of an equaliser when, with two players free, he failed to pass and ran into a crowd of defenders.

 The game ended in heated arguments after Inter’s last attack resulted in a free-kick being awarded to Juventus and the Inter forward Ivan Perisic being sent off.

 Two Parolo headers in the first 15 minutes gave Lazio a flying start at Pescara but the Dolphins hit back through Ahmad Benali and Gastón Brugman before half-time.

 In between Gianluca Caprari saw a weak penalty saved by Federico Marchetti, Pescara’s fifth miss from the spot in seven attempts this season.

 Parolo put Lazio back in front with another header straight after the re-start and completed the scoring with a volley. Keita Baldé and Ciro Immobile were also on target in between.

 The Sampdoria forward Luis Muriel sent Gianluigi Donnarumma the wrong way from the penalty spot in the 70th minute to hand Milan their third successive league defeat after Gabriel Paletta fouled Fabio Quagliarella.

 Milan, now in eighth place and struggling to qualify for Europe, had things go from bad to worse when José Sosa was booked twice in five minutes and sent off.

 Andrea Belotti volleyed Torino in front at Empoli with his 15th goal of the season but the home side levelled when Arlind Ajeti’s backpass got stuck in a puddle, allowing Manuel Pucciarelli to pounce on the loose ball,  go around Joe Hart and score. Iago Falque became the third Torino player to miss a penalty this season when his effort was saved by Lukasz Skorupski in the 55th minute.